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Taking certain drugs with colchicine can cause dangerous effects in the bodyExamples of drugs you should not use with colchicine include:
Physicians should ensure that patients are suitable candidates for treatment with colchicine capsules and remain alert for signs and symptoms of toxic reactions associated with increased colchicine exposure due to drug interactionsSigns and symptoms of colchicine toxicity should be evaluated promptly andif toxicity is suspectedcolchicine capsules should be discontinued immediately.
This medicinal product contains lactosePatients with rare hereditary problems of galactose intolerancethe Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Colchicine is a substrate for both CYP3A4 and the transport protein P-gpIn the presence of CYP3A4 or P-gp inhibitorsthe concentrations of colchicine in the blood increaseToxicityincluding fatal caseshave been reported during concurrent use of CYP3A4 or P-gp inhibitors such as macrolidesclarithromycin and erythromycinciclosporinketoconazoleitraconazolevoriconazoleHIV protease inhibitorscalcium channel blockersverapamil and diltiazemand disulfiramsee section 4.4
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take colchicine exactly as directed.