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The active substance in Viramunenevirapineis a non-nucleoside reverse-transcriptase inhibitorNNRTIIt blocks the activity of reverse transcriptasean enzyme produced by HIV-1 that allows it to infect cells in the body and make more virusesBy blocking this enzymeViramunetaken in combination with other antiviral medicinesreduces the amount of HIV-1 in the blood and keeps it at a low levelViramune does not cure HIV-1 infection or AIDSbut it may delay the damage to the immune system and the development of infections and diseases associated with AIDS.
In the multinational 2NN studya population pharmacokinetic substudy of 1,077 patients was performed that included 391 femalesFemale patients showed a 13.8lower clearance of nevirapine than did male patientsThis difference is not considered clinically relevantSince neither body weight nor Body Mass IndexBMIhad influence on the clearance of nevirapinethe effect of gender cannot be explained by body sizeNevirapine pharmacokinetics in HIV-1 infected adults does not appear to change with agerange 19-68 yearsor raceBlackHispanicor CaucasianNevirapine has not been specifically investigated in patients over the age of 65.
The dose should not be increased to the maintenance dose until any rash has clearedIf the patient cannot switch to the full dose within four weeks of starting Viramunealternative treatments should be sought.
The simultaneous use of nevirapine400 mgplus efavirenz800 mgwas associated with the highest frequency of clinical adverse events and with the highest rate of treatment failure53.1As the regimen of nevirapine plus efavirenz did not have additional efficacy and caused more adverse events than each medicinal product separatelythis regimen is not recommended.
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